Case Report

Kikuchi Disease in Elderly: Report of a Rare Disease in an Unusual Age


Kikuchi disease is a benign, self-limited, and rare condition presented mainly by lymphadenopathy and fever. Kikuchi disease is more common in women, especially women under 40. We report a 63-year-old Iranian woman presenting with long-term fever, constitutional symptoms, and cervical lymphadenopathy. A lymph node biopsy was done for her, and the diagnosis of Kikuchi disease was confirmed. Kikuchi disease is a self-limited condition with a good prognosis that can resolve with no specific treatment within a few weeks. Still, some patients are at risk of recurrence and development of SLE and Lymphoma. Our patient was treated with a low dose of glucocorticoids. On 6 month follow-up, she had no signs and symptoms of recurrence and no evidence of SLE development. The interesting point of this case is the clinical picture and her age of presentation.

[1] Yegneswaran B, Jain V. Self-limited disorder in a young female with fever, abdominal pain and lymphadenopathy: A case report. Cases Journal. 2009; 2(1):9318. [DOI:10.1186/1757-1626-2-9318] [PMID] [PMCID]
[2] Huh J, Kang GH, Gong G, Kim SS, Ro JY, Kim CW. Kaposi’s sarcoma- associated herpesvirus in Kikuchi’s disease. Human Pathology. 1998; 29(10):1091-6. [DOI:10.1016/S0046-8177(98)90419-1] [PMID]
[3] Lee KY, Yeon YH, Lee BC. Kikuchi-Fujimoto disease with prolonged fever in children. Pediatrics. 2004; 114(6):e752-e6. [DOI:10.1542/ peds.2004-0485] [PMID][4] Payne J, Evans M, Gerrard M. Kikuchi-Fujimoto disease: A rare but important cause of lymphadenopathy. Acta Paediatrica. 2003; 92(2):261-4. [DOI:10.1111/j.1651-2227.2003.tb00539.x] [PMID]
[5] Ray A, Muse VV, Boyer DF. Case records of the Massachusetts general hospital. Case 38-2013. A 30-year-old man with fever and lymphadenopathy. New England Journal of Medicine. 2013; 369(24):2333-43. [DOI:10.1056/NEJMcpc1310002] [PMID]
[6] Naito N, Shinohara T, Machida H, Hino H, Naruse K, Ogushi F. Ki- kuchi-Fujimoto disease associated with community acquired pneu- monia showing intrathoratic lymphadenopathy without cervical le- sions. SpringerPlus. 2015; 4:693. [DOI:10.1186/s40064-015-1500-y] [PMID] [PMCID]
[7] Hino H, Nishimura T, Nitadori J, Miyakoshi S, Seki A, Arai T, et al. An uncommon presentation of Kikuchi-Fujimoto disease as mediasti- nal lymphadenopathy. Journal of Thoracic Disease. 2016; 8(5):E330. [DOI:10.21037/jtd.2016.03.78] [PMID] [PMCID]
[8] Kuo TT. Kikuchi’s disease (histiocytic necrotizing lymphadenitis). A clinicopathologic study of 79 cases with an analysis of histologic sub- types, immunohistology, and DNA ploidy. The American Journal of Surgical Pathology. 1995; 19(7):798-809. [DOI:10.1097/00000478- 199507000-00008] [PMID]
[9] Ruaro B, Sulli A, Alessandri E, Fraternali-Orcioni G, Cutolo M. kikuchi-Fujimto disease associated with systemic lupus erythe- matous: Difficult case report and literature review. Lupus. 2014; 23(9):939-44. [DOI:10.1177/0961203314530794] [PMID]
[10] Asano S, Akaike Y, Jinnouchi H, Muramatsu T, Wakasa H. Necrotiz- ing lymphadenitis: A review of clinicopathological, immunohis- tochemical and ultrastructural studies. Hematological Oncology. 1990; 8(5):251-60. [DOI:10.1002/hon.2900080503] [PMID]
[11] Mital D, Desai V, Chin K. Kikuchi-Fujimoto syndrome presenting to a sexual health clinic. International Journal of STD & AIDS. 2009; 20(2):140-1. [DOI:10.1258/ijsa.2008.008291] [PMID]
[12] Nieman R. Diagnosis of Kikuchi’s disease. The Lancet. 1990; 335(8684):295. [DOI:10.1016/0140-6736(90)90116-M][PMID]
[13] Lin DY, Villegas MS, Tan PL, Wang S, Shek LP. Severe Kikuchi’s dis- ease responsive to immune modulation. Singapore Medical Jour- nal. 2010; 51(1):e18-21. [PMID]
[14] Tariq H, Gaduputi V, Rafiq A, Shenoy R. The enigmatic Kikuchi-Fuji- moto disease: A case report and review. Case Reports in Hematology. 2014; 2014:648136. [DOI:10.1155/2014/648136] [PMID] [PMCID]
[15] Vivekanandarajah A, Krishnarasa B, Hurford M, Gupta S. Kikuchi’s disease: A rare cause of fever and lymphadenopathy. Clinical Medi- cine Insights Pathology. 2012; 5:7-10. [DOI:10.4137/CPath.S8685] [PMID] [PMCID]
IssueVol 7 No 1 (2022): January-February QRcode
SectionCase Report(s)
Kikuchi disease Systemic lupus erythematosus Fever Lymphadenopathy Elderly

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How to Cite
Sahebi E, Karimpour Reyhan S, Abbaszadeh M, Khajavi Rad N. Kikuchi Disease in Elderly: Report of a Rare Disease in an Unusual Age. CRCP. 2022;7(1):1-5.