Cold Agglutinin-induced Hemolytic Anemia as the Primary Presentation in Systematic Lupus Erythematosus (SLE) in Pregnancy Triggered by Infection: A Case Report
-
Vajihe Marsusi
,
Ashraf Sadat Jamal
,
Laleh Eslamian
,
Maasoumeh Saleh
,
Behnaz Nouri
,
Danial Dehghan
Abstract
Autoimmune hemolytic anemia (AIHA) may be the first manifestation of systematic lupus erythematosus (SLE). Antierythrocyte antibodies in SLE are mainly warm-type Immunoglobulin G (IgG), but mixed-type AIHA is also reported. Cold antibody-mediated hemolytic anemia is extremely rare in SLE. Only a few cases have been reported in the literature. A 37-year-old pregnant woman presented with features of hemolytic anemia and was later diagnosed as an SLE case. Although rare, a new case report highlights that cold-type autoimmune hemolytic anemia may be an early manifestation of SLE.
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[8] Gertz MA. Management of cold hemolytic syndrome. British Journal of Haematology. 2007; 138(4):422-9. [DOI:10.1111/j.1365- 2141.2007.06664.x] [PMID]
[2] Findlater RR, Schnell-Hoehn KN. When blood runs cold: Cold ag- glutinins and cardiac surgery. Canadian Journal of Cardiovascular Nursing. 2011; 21(2):30-4. [PMID]
[3] Berentsen S, Barcellini W, D'Sa S, Randen U, Tvedt THA, Fattizzo B, et al. Cold agglutinin disease revisited: A multinational, observation- al study of 232 patients. Blood. 2020; 136(4):480-8. [DOI:10.1182/ blood.2020005674] [PMID]
[4] Ulvestad E, Berensten S, Mollnes TE. Acute phase hemolysis in chronic cold agglutinin disease. Scandinavian Journal of Immunolo- gy. 2001; 54(1-2):239-42. [DOI:10.1046/j.1365-3083.2001.00960.x] [PMID]
[5] Swiecicki PL, Hegerova LT, Gertz MA. Blood. 2013; 122(7):1114-21. [DOI:10.1182/blood-2013-02-474437] [PMID]
[6] Mohanty B, Ansari MZ, Kumari P, Sunder A. Cold agglutinin-induced hemolytic anemia as the primary presentation in SLE: A case report. Journal of Family Medicine and Primary Care. 2019; 8(5):1807-8. [DOI:10.4103/jfmpc.jfmpc_298_19] [PMID] [PMCID]
[7] Berentsen S, Ulvestad E, Langholm R, Beiske K, Hjorth-Hansen H, Ghanima W, et al. Primary chronic cold agglutinin disease: A pop- ulation-based clinical study of 86 patients. Haematologica. 2006; 91(4):460-6. [PMID]
[8] Gertz MA. Management of cold hemolytic syndrome. British Journal of Haematology. 2007; 138(4):422-9. [DOI:10.1111/j.1365- 2141.2007.06664.x] [PMID]
| Files | ||
| Issue | Vol 6 No S1 (2021): Supplementary | |
| Section | Case Report(s) | |
| Keywords | ||
| Pregnancy Autoimmune hemolytic anemia Cold agglutinins Systemic Lupus Erythematosus | ||
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Marsusi V, Jamal AS, Eslamian L, Saleh M, Nouri B, Dehghan D. Cold Agglutinin-induced Hemolytic Anemia as the Primary Presentation in Systematic Lupus Erythematosus (SLE) in Pregnancy Triggered by Infection: A Case Report. CRCP. 2022;6(S1):288-291.
