Case Report

Acute Inflammatory Demyelinating Polyneuropathy and Bilateral Anterior Uveitis as the Presenting Manifestations of Hodgkin’s Lymphoma

Abstract

Peripheral neuropathy is rarely the initial presentation of lymphoma. Acute inflammatory demyelinating sensorimotor neuropathy, meeting the diagnostic criteria of Guillain-Barré syndrome, might be associated with Hodgkin’s lymphoma. A 33-yearold woman presented with dyspnea, generalized lymphadenopathy, acute-onset progressive ascending muscle weakness of the lower extremities, and acute bilateral uveitis. EMG-NCV confirmed acute inflammatory demyelinating polyneuropathy. Malignant lymphoma was suspected. A core needle biopsy of the left axillary lymph node was performed and revealed the classic type of Hodgkin’s lymphoma. The ABVD regimen was administered along with five consecutive sessions of plasmapheresis.
The neurological signs and symptoms improved gradually. In conclusion, acute inflammatory demyelinating polyneuropathy mimicking Guillain-Barré syndrome might be associated with HL and precede the diagnosis of lymphoma. Therefore, clinicians need to be aware of the neurological manifestations of lymphoma for
appropriate diagnosis and treatment.

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IssueVol 10 No 4 (2025): July-August QRcode
SectionCase Report(s)
DOI https://doi.org/10.18502/crcp.v10i4.21111
Keywords
Hodgkin’s lymphoma Guillain-barré syndrome Neuropathy Uveitis
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How to Cite
1.
Assar S, Pournazari M, Mohamadzadeh D. Acute Inflammatory Demyelinating Polyneuropathy and Bilateral Anterior Uveitis as the Presenting Manifestations of Hodgkin’s Lymphoma. CRCP. 2026;10(4):176-180.