Radiological Presentation of a Patient With Multiple Sclerosis and Hepatic Disorder
In this case study, we presented the radiological characteristics of a 43-year-old female patient diagnosed with Multiple Sclerosis (MS). Following mitoxantrone administration, she developed liver failure. Magnetic Resonance Imaging (MRI) revealed multiple periventricular lesions in T2 and bilateral involvement of putamen and Globus Pallidus (GP) areas in T1 sequences.
 Antonazzo IC, Poluzzi E, Forcesi E, Riise T, Bjornevik K, Baldin E, et al. Liver injury with drugs used for multiple sclerosis: A contemporary analysis of the FDA adverse event reporting system. Multiple Sclerosis Journal. 2019; 25(12):1633-40. [DOI:10.1177/1352458518799598] [PMID]
 Doosti R, Togha M, Moghadasi AN, Aghsaie A, Azimi AM, Khorramnia S, et al. Evaluation of the risk of cervical cancer in patients with Multiple Sclerosis treated with cytotoxic agents: A cohort study. Iranian Journal of Neurology. 2018; 17(2):64-70. [PMID] [PMCID]
 Kingwell E, Koch M, Leung B, Isserow S, Geddes J, Rieckmann P, et al. Cardiotoxicity and other adverse events associated with mitoxantrone treatment for MS. Neurology. 2010; 74(22):1822-6. [DOI:10.1212/WNL.0b013e3181e0f7e6] [PMID] [PMCID]
 Llesuy SF, Arnaiz SL. Hepatotoxicity of mitoxantrone and doxorubicin. Toxicology. 1990; 63(2):187-98. [DOI:10.1016/0300- 483X(90)90042-F] Salehizadeh
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