Sudden Increase of Antipsychotics and Induction of Deep Vein Thrombosis
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Abstract
Introduction: Antipsychotics (APs) can induce pathological blood clotting. Deep Vein Thrombosis (DVT) is a common type of Venous Thromboembolism (VTE) and a significant cause of morbidity and mortality worldwide. First or second generation APs have been specifically correlated with an increased risk of thromboembolism.
Case presentation: We report a case of a bipolar female patient who developed DVT following an increase in her daily dose of APs (olanzapine and chlorpromazine).
Conclusion: Physicians in other medical fields, including internal medicine and surgery, should be trained about the complication of DVT induced by APs.
[1] Ferraris A, Szmulewicz AG, Vazquez FJ, Vollmer WM, Angriman F. Antipsychotic use among adult outpatients and venous thromboembolic disease: A retrospective cohort study. Journal of Clinical Psychopharmacology. 2017; 37(4):405-11. [DOI:10.1097/ JCP.0000000000000738] [PMID]
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[3] Joshi N, Singh P, Thapa M, Gautam S. Olanzapine induced DVT: A case report. Journal of Psychiatrists’ Association of Nepal. 2014; 3(1):41-2. [DOI:10.3126/jpan.v3i1.11351]
[4] Abou Taam M. Thrombosis and antipsychotics. Journal of Blood Disorders. 2015; 2(3):1030. file:///C:/Users/MARYAM/Downloads/ blooddisorders-v2-id1030.pdf
[5] Keles E, Ulasli SS, Basaran NC, Babaoglu E, Koksal D. Acute massıve pulmonary embolism assocıated wıth olanzapıne. The American Journal of Emergency Medicine. 2017; 35(10):1582.e5-e7. [DOI:10.1016/j.ajem.2017.07.026]
[6] Rarrick C, Saccone N, Hebbard A, Jones B. Assessing the rate of antipsychotic use in ambulatory care patients with a venous thromboembolism. Annals of Pharmacotherapy. 2020; 54(2):97-104. [DOI:10.1177/1060028019870874] [PMID]
[7] Dijkstra ME, van der Weiden CFS, Schol-Gelok S, Muller-Hansma AHG, Cohen G, van den Bemt PMLA, et al. Venous thrombosis during olanzapine treatment: A complex association. The Netherlands Journal of Medicine. 2018; 76(6):263-8. https://databankws.lareb. nl/Downloads/2018_3_venous_thrombosis_olanzapine_neth_J_ med.pdf
[8] Masopust J, Bazantova V, Kuca K, Klimova B, Valis M. Venous thromboembolism as an adverse effect during treatment with olanzapine: A case series. Frontiers in Psychiatry. 2019; 10:330. [DOI:10.3389/ fpsyt.2019.00330] [PMID] [PMCID]
[2] Bevis PM, Smith FCT. Deep vein thrombosis. Surgery. 2016; 34(4):159-64. [DOI:10.1016/j.mpsur.2016.02.001]
[3] Joshi N, Singh P, Thapa M, Gautam S. Olanzapine induced DVT: A case report. Journal of Psychiatrists’ Association of Nepal. 2014; 3(1):41-2. [DOI:10.3126/jpan.v3i1.11351]
[4] Abou Taam M. Thrombosis and antipsychotics. Journal of Blood Disorders. 2015; 2(3):1030. file:///C:/Users/MARYAM/Downloads/ blooddisorders-v2-id1030.pdf
[5] Keles E, Ulasli SS, Basaran NC, Babaoglu E, Koksal D. Acute massıve pulmonary embolism assocıated wıth olanzapıne. The American Journal of Emergency Medicine. 2017; 35(10):1582.e5-e7. [DOI:10.1016/j.ajem.2017.07.026]
[6] Rarrick C, Saccone N, Hebbard A, Jones B. Assessing the rate of antipsychotic use in ambulatory care patients with a venous thromboembolism. Annals of Pharmacotherapy. 2020; 54(2):97-104. [DOI:10.1177/1060028019870874] [PMID]
[7] Dijkstra ME, van der Weiden CFS, Schol-Gelok S, Muller-Hansma AHG, Cohen G, van den Bemt PMLA, et al. Venous thrombosis during olanzapine treatment: A complex association. The Netherlands Journal of Medicine. 2018; 76(6):263-8. https://databankws.lareb. nl/Downloads/2018_3_venous_thrombosis_olanzapine_neth_J_ med.pdf
[8] Masopust J, Bazantova V, Kuca K, Klimova B, Valis M. Venous thromboembolism as an adverse effect during treatment with olanzapine: A case series. Frontiers in Psychiatry. 2019; 10:330. [DOI:10.3389/ fpsyt.2019.00330] [PMID] [PMCID]
| Files | ||
| Issue | Vol 5 No 1 (2020): Winter | |
| Section | Case Report(s) | |
| DOI | https://doi.org/10.18502/crcp.v5i1.3610 | |
| Keywords | ||
| Antipsychotics Olanzapine Deep vein thrombosis Venous thromboembolism | ||
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Fariborzifar A, Elyasi F, Azizi M. Sudden Increase of Antipsychotics and Induction of Deep Vein Thrombosis. CRCP. 2020;5(1):23-26.
