Large Adrenal Ganglioneuroma Presenting with Clinical Pheochromocytoma: A Rare Case Report
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Abstract
Adrenal ganglioneuromas are rare benign and non-secretory neoplasms that, in the majority of cases, are unexpectedly discovered during imaging studies. In this study, we reported a large adrenal ganglioneuromas in a young patient, clinically presented as a pheochromocytoma. Laboratory evaluation and tumor markers were also report- ed in the normal range. The mass was then resected through laparoscopy. Ultimate- ly, histopathology revealed the diagnosis of Ganglioneuroma. Large adrenal gangli- oneuromas can be resected laparoscopically without any complications. An accurate pathological examination is usually essential for definitive diagnosis. Prognosis of ma- ture adrenal ganglioneuromas is excellent.
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16. Zhang Y, Nishimura H, Kato S, Fujimoto K, Ohkuma K, Kojima K, et al. MRI of ganglioneuroma: histologic correlation study. Journal of Computer Assisted Tomography. 2001; 25(4): 617- 23. DOI: 10.1097/00004728-200107000-00018
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19. Zvizdic Z, Haxhija E, Chikha A, Milisic E, Jonuzi A, Vranic S. Laparoscopic Extirpation of Adrenal Gland Ganglioneuroma Incidentally Diagnosed during Evaluation for Patchy Alopecia Areata in an Adolescent Boy. Medical Principles and Practice. 2019; 28:485–9. DOI: 10.1159/000499755
2. Rha SE, Byun JY, Jung SE, Chun HJ, Lee HG, Lee JM. Neurogenic tumours in the abdomen: tumour types and imaging characteristics. Radiographics. 2003; 23(1):29–43. DOI: 10.1148/rg.231025050
3. Carsote M, Ghemigian A, Terzea D, Gheorghisan-Galateanu AA, Valea A. Cystic adrenal lesions: focus on pediatric population (a review). Clujul Medical. 2017; 90(1): 5-12. DOI: 10.15386/ cjmed-677
4. K. Santosh, Manoj K. Das, Pavithra Ayyanar, Swarnendu Mandal, Prasant Nayak, Sumit Kumar. Laparoscopic excision of a large Adrenal Ganglioneuroma masquerading as Pheochromocytoma- A case report & review of literature. Urology Case Reports. 2020; 33:101276. DOI: 10.1016/j. eucr.2020.101276
5. NIH state-of-the-science statement on management of the clinically inapparent adrenal mass (“incidentaloma”). NIH Consens State Sci Statements. 2002; 19(2):1–25. Link
6. Rao RN, Singla N, Yadav K: Composite pheochromocytoma- ganglioneuroma of the adrenal gland: A case report with immunohistochemical study. Urology Annals. 2013; 5(2): 115– 8. DOI: 10.4103/0974-7796.110011
7. Iacobone M, Torresan F, Citton M, Schiavone D, Viel G, Favia G. Adrenal ganglioneuroma: The Padua Endocrine Surgery Unit experience. International Journal of Surgery. 2017; 41(Suppl 1):S103–8. DOI: 10.1016/j.ijsu.2017.03.086
8. Zografos GN, Korkolis D, Georgoutsos P, Antypa F, Ageli C, Fragia K, et al. Giant myelolipoma of the right adrenal gland. International Journal of Clinical Practice. 2002; 56(4):319 –320.
9. Shawa H, Elsayes KM, Javadi S, Morani A, Williams M.D, Lee J.E, et al. Adrenal ganglioneuroma: features and outcomes of 27 cases at a referral cancer center. Clinical Endocrinology (Oxf). 2014; 80 (3):342–7. DOI: 10.1111/cen.12320
10. Zugor V, Schott GE, Kühn R, Labanaris AP. Retroperitoneal ganglioneuroma in childhood--a presentation of two cases. Pediatrics and Neonatology. 2009; 50(4): 173-6. DOI: 10.1016/ S1875-9572(09)60058-9
11. Diab DL, Faiman C, Siperstein AE, Zhou M, Zimmerman RS. Virilizing adrenal ganglioneuroma in a woman with subclinical Cushing syndrome. Endocrine Practice.2008; 14(5): 584-7. DOI: 10.4158/EP.14.5.584
12. Lonergan GJ, Schwab CM, Suarez ES, Carlson CL. Neuroblastoma, ganglioneuroblastoma, and ganglioneuroma: radiologic- pathologic correlation. Radiographics .2002; 22(4): 911-34. DOI: 10.1148/radiographics.22.4.g02jl15911
13. Majbar AM, Elmouhadi S, Elaloui M, Raiss M, Sabbah F, Hrora A, et al.Imaging features of adrenal ganglioneuroma: a case report. BMC Research Notes .2014; 7: 791. DOI: 10.1186/1756- 0500-7-791
14. Fassnacht M, Kenn W, Allolio B: Adrenal tumors: how to establish malignancy? Journal of Endocrinological Investigation. 2004; 27(4):387–99. DOI: 10.1007/BF03351068
15. Mylonas K.S, Schizas D, Economopoulos K.P. Adrenal ganglioneuroma: What you need to know. World Journal of Clinical Cases. 2017; 16 (10): 373-7. DOI: 10.12998/wjcc. v5.i10.373
16. Zhang Y, Nishimura H, Kato S, Fujimoto K, Ohkuma K, Kojima K, et al. MRI of ganglioneuroma: histologic correlation study. Journal of Computer Assisted Tomography. 2001; 25(4): 617- 23. DOI: 10.1097/00004728-200107000-00018
17. Ilias I, Shulkin B, Pacak K. New functional imaging modalities for chromaffin tumors, neuroblastomas and ganglioneuromas. Trends in Endocrinology & Metabolism. 2005; 16(2):66 –72. DOI: 10.1016/j.tem.2005.01.007
18. Henry JF, Sebag F, Iacobone M, Mirallie E. Results of laparoscopic adrenalectomy for large and potentially malignant tumors. World Journal of Surgery. 2002; 26(8):1043–7. DOI: 10.1007/ s00268-002-6666-0
19. Zvizdic Z, Haxhija E, Chikha A, Milisic E, Jonuzi A, Vranic S. Laparoscopic Extirpation of Adrenal Gland Ganglioneuroma Incidentally Diagnosed during Evaluation for Patchy Alopecia Areata in an Adolescent Boy. Medical Principles and Practice. 2019; 28:485–9. DOI: 10.1159/000499755
| Files | ||
| Issue | Vol 7 No 4 (2022): July-August | |
| Section | Case Report(s) | |
| DOI | https://doi.org/10.18502/crcp.v7i4.11590 | |
| Keywords | ||
| Ganglioneuroma Laparoscopic adrenalectomy Adrenal tumor | ||
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How to Cite
1.
Farashi E, Rasihashemi SZ, Halimi M. Large Adrenal Ganglioneuroma Presenting with Clinical Pheochromocytoma: A Rare Case Report. CRCP. 2023;7(4):167-171.
