The Rare Instance of Uterine Adenocarcinoma Metastasizing to the Skull Base, Manifesting as Blindness and Ptosis
Skull Base Metastasis
-
Zahra Sanayepasand
,
Shirin Irani
,
Mohammadreza Firouzifar
,
Seyede Misha Seyednia
,
Farrokh Heidari
Abstract
Metastasis to the skull base is a rare but serious complication of various malignancies. This case report discusses a 50-year-old woman with a history of advanced endometrialadenocarcinoma who presented with progressive headache, left-eye blindness, and ptosis. Imaging revealed a mass along the left optic nerve, raising suspicions of mucormycosis, but biopsy confirmed metastatic endometrial adenocarcinoma. Despite
undergoing skull base radiotherapy, the patient’s vision did not improve. This case underscores the importance of considering metastatic endometrial adenocarcinoma in differential diagnoses for skull base lesions, particularly when other conditions are ruled out. Accurate diagnosis requires careful integration of clinical, radiological, and histopathological data.
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[8] Cecchi PC, Kluge R, Schwarz A. Calvarial metastasis from endometrial carcinoma: Case report and review of the
literature. Asian J Neurosurg. 2014 Oct-Dec;9(4):242. https:// doi.org/10.4103/1793-5482.146648
[9] Kamath SM, Pingali S, Girish G, Harish K. Primary synchronous mesenteric neuroendocrine tumors: Report of a rare case with review of literature. J Cancer Res Ther. 2015 Jul-Sep;11(3):662. https://doi.org/10.4103/0973-1482.138108
[10] Austell PJ, Levinson JS, Plitt MA, Ghai R, Gattuso P, Rupcich CR, et al. Endometrial Sarcoma Metastasis to the
Pterygopalatine Fossa: A Case Report and Review of the Literature. Ear Nose Throat J. 2024;103(3):148-50. https://doi.
org/10.1177/0145561320983943
[11] Atarbashi-Moghadam S, Atarbashi-Moghadam F, Niazmand M, Shahrabi-Farahani S. Metastatic sarcomas of the oral acavity: A systematic review. J Stomatol Oral Maxillofac Surg. 2023:101656. https://doi.org/10.1016/j.jormas.2023.101656
[12] van den Heerik ASV, Horeweg N, de Boer SM, Bosse T, Creutzberg CL. Adjuvant therapy for endometrial cancer in the era of molecular classification: radiotherapy, chemoradiation and novel targets for therapy. Int J Gynecol Cancer. 2021;31(4). https://doi.org/10.1136/ijgc-2020-001822
[13] Sandru A, Voinea S, Panaitescu E, Blidaru A. Survival rates of patients with metastatic malignant melanoma. J Med Life. 2014 Oct-Dec;7(4):572-6. https://doi.org/10.1155/2014/843214
[2] González CS, Vivero CM, Castro JL. Paraneoplastic syndromes review: The great forgotten ones. Crit Rev Oncol
Hematol. 2022;174:103676. https://doi.org/10.1016/j. critrevonc.2022.103676
[3] Naumann RW. Endometrial Cancer. Gynecol Oncol. EvidenceBased Perioperative and Supportive Care. 2011:329-59.
https://doi.org/10.1002/9781118003435.ch10
[4] Cao W, Chen HD, Yu YW, Li N, Chen WQ. Changing profiles of cancer burden worldwide and in China: a secondary
analysis of the global cancer statistics 2020. Chin Med J (Engl). 2021;134(07):783-91. https://doi.org/10.1097/ CM9.0000000000001474
[5] Paredes P, Paño B, Díaz B, Vidal-Sicart S. Endometrial Cancer. Nuclear Medicine Manual on Gynaecological Cancers and Other Female Malignancies: Springer; 2022. p. 71-88. https:// doi.org/10.1007/978-3-031-05497-6_4
[6] Pigrau-Serrallach C, Rodríguez-Pardo D. Bone and joint tuberculosis. Eur Spine J. 2013;22:556-66. https://doi.
org/10.1007/s00586-012-2331-y
[7] Kaloostian PE, Chen H, Stippler M. Case report: Uterine adenocarcinoma metastasis to the skull base and cervical76 Sanayepasand Z et al. Skull Base Metastasis. CRCP. 2024; 9(2):73-76 March/April 2024, Volume 9, Issue 2 spine presenting with pathological fracture and myelopathy. 2013;3(3):33-5. https://doi.org/10.4236/ojmn.2013.33007
[8] Cecchi PC, Kluge R, Schwarz A. Calvarial metastasis from endometrial carcinoma: Case report and review of the
literature. Asian J Neurosurg. 2014 Oct-Dec;9(4):242. https:// doi.org/10.4103/1793-5482.146648
[9] Kamath SM, Pingali S, Girish G, Harish K. Primary synchronous mesenteric neuroendocrine tumors: Report of a rare case with review of literature. J Cancer Res Ther. 2015 Jul-Sep;11(3):662. https://doi.org/10.4103/0973-1482.138108
[10] Austell PJ, Levinson JS, Plitt MA, Ghai R, Gattuso P, Rupcich CR, et al. Endometrial Sarcoma Metastasis to the
Pterygopalatine Fossa: A Case Report and Review of the Literature. Ear Nose Throat J. 2024;103(3):148-50. https://doi.
org/10.1177/0145561320983943
[11] Atarbashi-Moghadam S, Atarbashi-Moghadam F, Niazmand M, Shahrabi-Farahani S. Metastatic sarcomas of the oral acavity: A systematic review. J Stomatol Oral Maxillofac Surg. 2023:101656. https://doi.org/10.1016/j.jormas.2023.101656
[12] van den Heerik ASV, Horeweg N, de Boer SM, Bosse T, Creutzberg CL. Adjuvant therapy for endometrial cancer in the era of molecular classification: radiotherapy, chemoradiation and novel targets for therapy. Int J Gynecol Cancer. 2021;31(4). https://doi.org/10.1136/ijgc-2020-001822
[13] Sandru A, Voinea S, Panaitescu E, Blidaru A. Survival rates of patients with metastatic malignant melanoma. J Med Life. 2014 Oct-Dec;7(4):572-6. https://doi.org/10.1155/2014/843214
| Files | ||
| Issue | Vol 9 No 2 (2024): March-April | |
| Section | Case Report(s) | |
| DOI | https://doi.org/10.18502/crcp.v9i2.16928 | |
| Keywords | ||
| Skull base metastasis Endometrial adenocarcinoma Optic nerve Compression Blindness Ptosis | ||
| Rights and permissions | |
|
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Sanayepasand Z, Irani S, Firouzifar M, Seyednia SM, Heidari F. The Rare Instance of Uterine Adenocarcinoma Metastasizing to the Skull Base, Manifesting as Blindness and Ptosis. CRCP. 2024;9(2):70-73.
