Case Report

Benign Metastasizing Leiomyoma of the Lung: A Case Report

Abstract

Benign metastasizing leiomyoma of the lung which is categorized by the growth of uterine leiomyoma in the lung is an extremely exceptional disease.We report a 39-year-old woman who had a previous history of uterine leiomyoma. Chest computed tomography (CT) scan exhibited round nodules well-defined margins in both lungs. Thoracoscopic partial resection of the lung was done. Pathological and immunohistochemical examination showed that neoplastic tissue composed of spindle-shaped smooth muscle cells, compatible with uterine leiomyoma. Thus, these tumors can be reflected to be lung metastases from a uterine leiomyoma (benign metastasizing leiomyoma).It is an uncommon condition but it would be careful in women of re- productive age with a past medical history of uterine leiomyoma, who existing with pulmonary nodules.

[1] Awonuga AO, Shavell VI, Imudia AN, Rotas M, Diamond MP, Puscheck EE. Pathogenesis of benign metastasizing leiomyoma: a review. Obstetrical & gynecological survey. 2010;65(3):189-95. https://doi.org/10.1097/OGX.0b013e3181d60f93
[2] Nucci MR, Drapkin R, Dal Cin P, Fletcher CD, Fletcher JA. Distinctive cytogenetic profile in benign metastasizing leiomyoma: pathogenetic implications. The American journal of surgical pathology. 2007;31(5):737-43. https://doi. org/10.1097/01.pas.0000213414.15633.4e
[3] Ki EY, Hwang SJ, Lee KH, Park JS, Hur SY. Benign metastasizing leiomyoma of the lung. World Journal of Surgical Oncology. 2013;11(1):1-7. https://doi.org/10.1186/1477-7819-11-279
[4] Fan D, Yi X. Pulmonary benign metastasizing leiomyoma: a case report. International journal of clinical and experimental pathology. 2014;7(10):7072-75. PMID: 25400799
[5] Saadeh FA, Riain CO, Mc Cormack C, Gleeson N. Lung metastases from benign uterine leiomyoma: does 18-FDG-PET/ CT have a role to play? Irish Journal of Medical Science (1971). 2019;188(2):619-24.https://doi.org/10.1007/s11845-018- 1876-0
[6] Loukeri AA, Pantazopoulos IN, Tringidou R, Giampoudakis P, Valaskatzi A, Loukeri PA, et al. Benign metastasizing leiomyoma presenting as cavitating lung nodules. Respiratory care. 2014;59(7):e94-e7.https://doi.org/10.4187/respcare.02775
[7] Kayser K, Zink S, Schneider T, Dienemann H, André S, Kaltner H, et al. Benign metastasizing leiomyoma of the uterus: documentation of clinical, immunohistochemical and lectin-histochemical data of ten cases. Virchows Archiv. 2000;437(3):284-92. https://doi.org/10.1007/s004280000207
[8] Wei WT, Chen PC. Benign metastasizing leiomyoma of the lung: A case report and literature review. Oncology letters. 2015;10(1):307-12. https://doi.org/10.3892/ol.2015.3224
[9] Chen S, Liu R-M, Li T. Pulmonary benign metastasizing leiomyoma: a case report and literature review. Journal of thoracic disease. 2014;6(6):E92.
[10] Rege AS, Snyder JA, Scott WJ. Benign metastasizing leiomyoma: a rare cause of multiple pulmonary nodules. The Annals of thoracic surgery. 2012;93(6):e149-e51. https://doi. org/10.1016/j.athoracsur.2011.12.047
[11] Fu Y, Li H, Tian B, Hu B. Pulmonary benign metastasizing leiomyoma: a case report and review of the literature. World journal of surgical oncology. 2012;10(1):1-4. https://doi. org/10.1186/1477-7819-10-268
[12] Tsunoda Y, Tanaka K, Hagiwara M. A case of benign metast- asizing leiomyoma of the lung complicated with primary lung cancer. Jpn J Lung Cancer. 2009;49:445-9. https://doi. org/10.2482/haigan.49.445
Files
IssueVol 7 No 2 (2022): March-April QRcode
SectionCase Report(s)
DOI https://doi.org/10.18502/crcp.v7i2.10825
Keywords
Leiomyoma Lung Metastasis

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
1.
Pazoki M, Nazar E, Jahanbin B. Benign Metastasizing Leiomyoma of the Lung: A Case Report. CRCP. 2022;7(2):86-90.